Endocrine Abstracts

We have earlier shown a reciprocal feed-forward amplification link between expression of transcription factor GATA-4 and luteinizing hormone receptor (LHR) during adrenocortical tumorigenesis, and also that chronically elevated LH levels may induce LHR in mice, but not GATA-4. Hereby, our goal was to analyze the consequences of ectopically expressed GATA-4 on murine adrenal cortex in the presence and absence of gonadectomy (GDX) induced elevated LH levels. For this purpose, we...